| Code | Faculty | Department |
|---|---|---|
| 02131010 | Faculty of Natural and Agricultural Sciences | Department: Physiology |
| Credits | Duration | NQF level |
|---|---|---|
| Minimum duration of study: 4 years | Total credits: 516 | NQF level: 07 |
This is an extended BSc degree programme with a four-year curriculum that is only presented on a full-time basis. It is designed to enable students, who show academic potential, to obtain a BSc degree.
This programme is directed at a general formative education in the natural sciences. It provides the student with a broad academic basis to continue with postgraduate studies and prepares the student for active involvement in a wide variety of career possibilities.
Important information for all prospective students for 2025
The admission requirements below apply to all who apply for admission to the University of Pretoria with a National Senior Certificate (NSC) and Independent Examination Board (IEB) qualifications. Click here for this Faculty Brochure.
Minimum requirements | |||
Achievement level | |||
English Home Language or English First Additional Language | Mathematics | Physical Sciences | APS |
NSC/IEB | NSC/IEB | NSC/IEB | |
58% | 58% | 58% | 30 |
Life Orientation is excluded when calculating the APS.
Applicants currently in Grade 12 must apply with their final Grade 11 (or equivalent) results.
Applicants who have completed Grade 12 must apply with their final NSC or equivalent qualification results.
Please note that meeting the minimum academic requirements does not guarantee admission.
Only students that have completed school in the last two years and have not studied at a tertiary institution will be considered for this programme.
Successful candidates will be notified once admitted or conditionally admitted.
Unsuccessful candidates will also be notified.
Applicants should check their application status regularly on the UP Student Portal at click here.
Applicants with qualifications other than the abovementioned should refer to the International undergraduate prospectus 2025: Applicants with a school leaving certificate not issued by Umalusi (South Africa), available at click here.
International students: Click here.
Academic promotion requirements
Students who do not show progress during the first semester of the first year will be referred to the Admissions Committee of the Faculty.
It is expected of students who register for the first year of the BSc four-year programmes to pass all the prescribed modules of the first year.
Progression requirement
The first year is foundational to the mainstream modules that follow; students will be limited to repeating two foundation modules during year 2 of study. Students may apply for internal transfers at the end of year 2. Not all mainstream programmes will be accessible; the Faculty’s transfer guide will clearly outline all possibilities and the overarching objective will be that approved transfers will not involve adding an additional year of study.
Minimum credits: 100
Fundamental = 20
Core = 80
Module content:
Find, evaluate, process, manage and present information resources for academic purposes using appropriate technology.
Module content:
Apply effective search strategies in different technological environments. Demonstrate the ethical and fair use of information resources. Integrate 21st-century communications into the management of academic information.
Module content:
The module aims to equip students with the ability to cope with the academic demands of scientific disciplines, with a strong focus on high order thinking skills and academic reading skills and strategies.
Module content:
The module aims to equip students with the ability to cope with the academic demands of scientific disciplines, with a strong focus on high order thinking skills and academic/scientific writing skills.
Module content:
In this module, students will embark on a journey to understand the nature and scope of biology, delving into its importance in unravelling the mysteries of life. They will explore the essential characteristics of living organisms, encompassing cellular structure, metabolic processes, growth, reproduction, and adaptation. The scientific method, serving as a structured framework for inquiry, hypothesis formulation, experimentation, and evidence-based conclusion making, will be examined. The molecular basis of life, encompassing carbohydrates, lipids, proteins, and nucleic acids, and their significance in cellular structure and function will be studied. The intricate workings of cells and organelles will be introduced, along with DNA structure and replication. Furthermore, they will explore the complexities of the cell cycle, including mitosis and meiosis, and their important roles in growth, development, and genetic inheritance. Hands-on laboratory activities will include microscope operation, specimen preparation, and techniques for calculating magnification.
Module content:
In this module, students will explore various aspects of biology and ecology, starting with metabolic pathways like cellular respiration and photosynthesis, elucidating how cells obtain and utilize energy. They will delve into evolutionary principles such as natural selection, adaptation, and speciation, and their role in shaping the diversity of life. The concept of taxonomy will be introduced, clarifying its role in categorizing organisms based on shared characteristics. Additionally, students will explore the tree of life as a visual representation of the evolutionary lineage of all living beings. Ecological concepts such as trophic levels, biodiversity hotspots, and ecosystem services will be discussed to emphasize their critical role in sustaining life on Earth. The module will also showcase Africa's remarkable biodiversity, ranging from its megafauna to its diverse array of plant and microbial life. Students will delve into conservation ecology within the context of Africa, analyzing strategies aimed at preserving biodiversity, addressing human-wildlife conflicts, and fostering sustainable development practices. Lastly, the module will address global challenges such as food security and climate change, examining their profound implications for humanity's future.
Module content:
The first semester of foundational chemistry will introduce scientific communication to students in terms of the language of chemistry and necessary mathematical skills. The semester will begin with an in-depth study of dimensional analysis which paves the way for mole concept calculations and complex stoichiometry. Chemical reactions, including equations, types of reactions and redox reactions will round off the first semester of study.
Module content:
The second semester of foundational chemistry will begin with naming, bonding and molecular geometries. Molecular geometry will form the basis for intermolecular forces, phases of matter and different domains of thinking within the chemistry discipline. Thinking on the macroscopic, submicroscopic and representational domains is essential for future scientists. Embedded throughout the course will be a systems thinking approach to chemistry, seeing chemistry as an integral part of a global whole.
Module content:
This module introduces the fundamental principles and tools of physics. Students will gain mastery in measurement techniques, data analysis through graphical representations, and dimensional analysis to identify hidden relationships. Subsequently, the module focuses on one-dimensional kinematics, emphasizing the concepts of position, velocity, and acceleration. Further exploration delves into longitudinal and transverse waves, investigating their properties and propagation mechanisms. The module then introduces physical optics, exploring the behaviour of light through lenses and the formation of images. Finally, the foundations of thermodynamics are established, focusing on the concepts of heat, temperature, and heat capacity.
Module content:
Building upon the previous semester, vector algebra will be introduced, including notation, addition, coordinate systems, and manipulation of magnitudes and angles. Kinematics expands to two- and three-dimensional motion, providing a comprehensive understanding of real-world scenarios. The core of the module focuses on mechanics, analysing the interplay of forces, inertia, and motion governed by Newton's laws. Concepts of momentum, impulse, and conservation laws are introduced. Further exploration investigates equilibrium of forces, friction, and the dynamics of circular motion. These concepts lead to energy principles including work, kinetic energy, the work-energy theorem and power, potential energy, conservative and non-conservative forces and collisions. The module concludes with an introduction to direct current circuits, exploring the flow of current in resistor-based circuits.
Module content:
Data literacy in modern society: fundamental understanding of data and its presentation. Data ethics, importing, cleaning, manipulation and handling. Sources and types of data. Sampling methods and the collection of data. Statistical concepts are demonstrated and interpreted through Excel (practical coding) and simulation within a data science framework.
Module content:
Exploratory data analysis: tabulation, data visualisation and descriptive measures of location and dispersion. Introduction to probability and counting techniques. Aims of data analysis: descriptive, inferential and predictive. Statistical concepts are demonstrated and interpreted through Excel (practical coding) and simulation within a data science framework.
Module content:
This module serves as an introduction to algebra, functions, sequences, and trigonometry, and it aims to deepen students’ conceptual understanding of real numbers, elementary set notation, exponents, radicals, algebraic expressions, fractional expressions, linear and quadratic equations, and inequalities. Coordinate geometry: lines, and circles are discussed. Functions are presented numerically, symbolically, graphically, and verbally, focusing on the definition, notation, piecewise-defined functions, domain and range, graphs, transformations of functions, symmetry, even and odd functions, combining functions, one-to-one functions and inverses, polynomial functions and zeros. Trigonometry: the relationship between degrees and radians measure is discussed, as well as the unit circle, trigonometric functions, fundamental identities, trigonometric graphs, trigonometric identities, double-angle, half-angle formulae, trigonometric equations, and applications.
Module content:
The second-semester mathematics module focuses on the mathematical order of numbers and applications: Arithmetic and geometric sequences and series, summation notation, infinite geometric series, compound interest, annuities and instalments, exponential and logarithmic equations, followed by the laws of logarithms. Furthermore, one-to-one functions are extended to exponential and logarithmic functions. An introduction to calculus focusing on finding limits numerically and graphically, finding limits algebraically, techniques for evaluating limits, and differentiation rules.
Minimum credits: 128
Core = 128
Please note: ANA modules can only be taken by BSc (Medical Science) students.
Module content:
Simple statistical analysis: Data collection and analysis: Samples, tabulation, graphical representation, describing location, spread and skewness. Introductory probability and distribution theory. Sampling distributions and the central limit theorem. Statistical inference: Basic principles, estimation and testing in the one- and two-sample cases (parametric and non-parametric). Introduction to experimental design. One- and twoway designs, randomised blocks. Multiple statistical analysis: Bivariate data sets: Curve fitting (linear and non-linear), growth curves. Statistical inference in the simple regression case. Categorical analysis: Testing goodness of fit and contingency tables. Multiple regression and correlation: Fitting and testing of models. Residual analysis. Computer literacy: Use of computer packages in data analysis and report writing.
Module content:
Botanical principles of structure and function; diversity of plants; introductory plant systematics and evolution; role of plants in agriculture and food security; principles and applications of plant biotechnology; economical and valuable medicinal products derived from plants; basic principles of plant ecology and their application in conservation and biodiversity management.
This content aligns with the United Nation's Sustainable Debelopment Goals of No Poverty, Good Health and Well-being, Climate Action, Responsible Consumption and Production, and Life on Land.
Module content:
General introduction to inorganic, analytical and physical chemistry. Atomic structure and periodicity. Molecular structure and chemical bonding using the VSEPR-model. Nomenclature of inorganic ions and compounds. Classification of reactions: precipitation, acid-base, redox reactions and gas-forming reactions. Mole concept and stoichiometric calculations concerning chemical formulas and chemical reactions. Principles of reactivity: energy and chemical reactions. Physical behaviour gases, liquids, solids and solutions and the role of intermolecular forces. Rate of reactions: Introduction to chemical kinetics.
Module content:
Theory: General physical-analytical chemistry: Chemical equilibrium, acids and bases, buffers, solubility equilibrium, entropy and free energy, electrochemistry. Organic chemistry: Structure (bonding), nomenclature, isomerism, introductory stereochemistry, introduction to chemical reactions and chemical properties of organic compounds and biological compounds, i.e. carbohydrates and aminoacids. Practical: Molecular structure (model building), synthesis and properties of simple organic compounds.
Module content:
Chromosomes and cell division. Principles of Mendelian inheritance: locus and alleles, dominance interactions, extensions and modifications of basic principles.. Probability studies. Sex determination and sex linked traits. Pedigree analysis. Genetic linkage and chromosome mapping. Chromosome variation.
Module content:
The module will introduce the student to the field of Microbiology. Basic Microbiological aspects that will be covered include introduction into the diversity of the microbial world (bacteria, archaea, eukaryotic microorganisms and viruses), basic principles of cell structure and function, microbial nutrition and microbial growth and growth control. Applications in Microbiology will be illustrated by specific examples i.e. bioremediation, animal-microbial symbiosis, plant-microbial symbiosis and the use of microorganisms in industrial microbiology. Wastewater treatment, microbial diseases and food will be introduced using specific examples.
Module content:
Introduction to the molecular structure and function of the cell. Basic chemistry of the cell. Structure and composition of prokaryotic and eukaryotic cells. Ultrastructure and function of cellular organelles, membranes and the cytoskeleton. General principles of energy, enzymes and cell metabolism. Selected processes, e.g. glycolysis, respiration and/or photosynthesis. Introduction to molecular genetics: DNA structure and replication, transcription, translation. Cell growth and cell division.
Module content:
Note: PHY 131 is aimed at students who will not continue with physics. PHY 131 cannot be used as a substitute for PHY 114.
Units, vectors, one dimensional kinematics, dynamics, work, equilibrium, sound, liquids, heat, thermodynamic processes, electric potential and capacitance, direct current and alternating current, optics, modern physics, radioactivity.
Module content:
*Students will not be credited for more than one of the following modules for their degree: WTW 134, WTW 165, WTW 114, WTW 158. WTW 134 does not lead to admission to Mathematics at 200 level and is intended for students who require Mathematics at 100 level only. WTW 134 is offered as WTW 165 in the second semester only to students who have applied in the first semester of the current year for the approximately 65 MBChB, or the 5-6 BChD places becoming available in the second semester and who were therefore enrolled for MGW 112 in the first semester of the current year.
Functions, derivatives, interpretation of the derivative, rules of differentiation, applications of differentiation, integration, interpretation of the definite integral, applications of integration. Matrices, solutions of systems of equations. All topics are studied in the context of applications.
Module content:
Animal classification, phylogeny organisation and terminology. Evolution of the various animal phyla, morphological characteristics and life cycles of parasitic and non-parasitic animals. Structure and function of reproductive,
respiratory, excretory, circulatory and digestive systems in various animal phyla. In-class discussion will address the sustainable development goals #3, 12, 13, 14 and 15 (Good Health and Well-being. Responsible Consumption and Production, Climate Action, Life Below Water, Life on Land).
Minimum credits: 144
Core = 108
Elective = 36
Additional information:
Single major track:
Dual major track:
Module content:
Structural and ionic properties of amino acids. Peptides, the peptide bond, primary, secondary, tertiary and quaternary structure of proteins. Interactions that stabilise protein structure, denaturation and renaturation of proteins. Introduction to methods for the purification of proteins, amino acid composition, and sequence determinations. Enzyme kinetics and enzyme inhibition. Allosteric enzymes, regulation of enzyme activity, active centres and mechanisms of enzyme catalysis. Examples of industrial applications of enzymes and in clinical pathology as biomarkers of diseases. Online activities include introduction to practical laboratory techniques and Good Laboratory Practice; techniques for the quantitative and qualitative analysis of biological molecules; enzyme activity measurements; processing and presentation of scientific data.
Module content:
Carbohydrate structure and function. Blood glucose measurement in the diagnosis and treatment of diabetes. Bioenergetics and biochemical reaction types. Glycolysis, gluconeogenesis, glycogen metabolism, pentose phosphate pathway, citric acid cycle and electron transport. Total ATP yield from the complete oxidation of glucose. A comparison of cellular respiration and photosynthesis. Online activities include techniques for the study and analysis of metabolic pathways and enzymes; PO ratio of mitochondria, electrophoresis, extraction, solubility and gel permeation techniques; scientific method and design.
Module content:
Chemical foundations. Weak interactions in aqueous systems. Ionisation of water, weak acids and weak bases. Buffering against pH changes in biological systems. Water as a reactant and function of water. Carbohydrate structure and function. Biochemistry of lipids and membrane structure. Nucleotides and nucleic acids. Other functions of nucleotides: energy carriers, components of enzyme cofactors and chemical messengers. Introduction to metabolism. Bioenergetics and biochemical reaction types. Online activities include introduction to laboratory safety and Good Laboratory Practice; basic biochemical calculations; experimental method design and scientific controls, processing and presentation of scientific data.
Module content:
Orientation in physiology, homeostasis, cells and tissue, muscle and neurophysiology, cerebrospinal fluid and the special senses.
Practical work: Practical exercises to complement the theory.
Module content:
Body fluids; haematology; cardiovascular physiology and the lymphatic system. Practical work: Practical exercises to complement the theory.
Module content:
Structure, gas exchange and non-respiratory functions of the lungs; structure, excretory and non-urinary functions of the kidneys, acid-base balance, as well as the skin and body temperature control.
Practical work: Practical exercises to complement the theory.
Module content:
Nutrition, digestion and metabolism; hormonal control of the body functions and the reproductive systems. Practical work: Practical exercises to complement the theory.
Module content:
The chemical nature of DNA. The processes of DNA replication, transcription, RNA processing, translation. Control of gene expression in prokaryotes and eukaryotes. Recombinant DNA technology and its applications in gene analysis and manipulation.
Module content:
Chromosome structure and transposable elements. Mutation and DNA repair. Genomics and proteomics. Organelle genomes. Introduction to genetic analysis of populations: allele and genotypic frequencies, Hardy Weinberg Law, its extensions and implications for different mating systems. Introduction to quantitative and evolutionary genetics.
Module content:
Biochemistry of lipids, membrane structure, anabolism and catabolism of lipids. Total ATP yield from the complete catabolism of lipids. Electron transport chain and energy production through oxidative phosphorylation. Nitrogen metabolism, amino acid biosynthesis and catabolism. Biosynthesis of neurotransmitters, pigments, hormones and nucleotides from amino acids. Catabolism of purines and pyrimidines. Therapeutic agents directed against nucleotide metabolism. Examples of inborn errors of metabolism of nitrogen containing compounds. The urea cycle, nitrogen excretion. Online activities include training in scientific reading skills; evaluation of a scientific report; techniques for separation analysis and visualisation of biological molecules; hypothesis design and testing, method design and scientific controls.
Module content:
Nitrogen metabolism in plants; nitrogen fixation in Agriculture; plant secondary metabolism and natural products; photosynthesis and carbohydrate metabolism in plants; applications in solar energy; plant growth regulation and the Green Revolution; plant responses to the environment; developing abiotic stress tolerant and disease resistant plants. Practicals: Basic laboratory skills in plant physiology; techniques used to investigate nitrogen metabolism, carbohydrate metabolism, pigment analysis, water transport in plant tissue and response of plants to hormone treatments.
Module content:
Theory: Classical chemical thermodynamics, gases, first and second law and applications, physical changes of pure materials and simple compounds. Phase rule: Chemical reactions, chemical kinetics, rates of reactions.
Module content:
Statistical evaluation of data in line with ethical practice, gravimetric analysis, aqueous solution chemistry, chemical equilibrium, precipitation-, neutralisation- and complex formation titrations, redox titrations, potentiometric methods, introduction to electrochemistry. Examples throughout the course demonstrate the relevance of the theory to meeting the sustainable development goals of clean water and clean, affordable energy.
Module content:
Resonance, conjugation and aromaticity. Acidity and basicity. Introduction to 13C NMR spectroscopy. Electrophilic addition: alkenes. Nucleophilic substitution, elimination, addition: alkyl halides, alcohols, ethers, epoxides, carbonyl compounds: ketones, aldehydes, carboxylic acids and their derivatives Training in an ethical approach to safety that protects self, others and the environment is integral to the practical component of the course.
Module content:
Atomic structure, structure of solids (ionic model). Coordination chemistry of transition metals: Oxidation states of transition metals, ligands, stereochemistry, crystal field theory, consequences of d-orbital splitting, electrochemical properties of transition metals in aqueous solution. Fundamentals of spectroscopy and introduction to IR spectroscopy. During practical training students learn to acquire and report data ethically. Practical training also deals with the misuse of chemicals and appropriate waste disposal to protect the environment and meet the UN sustainable development goals.
Module content:
Growth, replication and survival of bacteria, Energy sources, harvesting from light versus oxidation, regulation of catabolic pathways, chemotaxis. Nitrogen metabolism, iron-scavenging. Alternative electron acceptors: denitrification, sulphate reduction, methanogenesis. Bacterial evolution, systematic and genomics. Biodiversity; bacteria occurring in the natural environment (soil, water and air), associated with humans, animals, plants, and those of importance in foods and in the water industry.
Module content:
Organisation and molecular architecture of fungal thalli, chemistry of the fungal cell. Chemical and physiological requirements for growth and nutrient acquisition. Mating and meiosis; spore development; spore dormancy, dispersal and germination. Fungi as saprobes in soil, air, plant, aquatic and marine ecosystems; role of fungi as decomposers and in the deterioration of materials; fungi as predators and parasites; mycoses, mycetisms and mycotoxicoses; fungi as symbionts of plants, insects and animals. Applications of fungi in biotechnology.
Module content:
Primary sources of migroorganisims in food. Factors affecting the growth and survival of microorganisms in food. Microbial quality, spoilage and safety of food. Different organisms involved, their isolation, screening and detection. Conventional approaches, alternative methods rapid methods. Food fermentations: fermentation types, principles and organisms involved.
Module content:
Origin and extent of modern invertebrate diversity; parasites of man and domestic animals; biology and medical importance of arachnids and insects; insect life styles; the influence of the environment on insect life histories; insect herbivory; predation and parasitism; insect chemical, visual, and auditory communication. Examples used in the module are relevant to the sustainable development goals of Life on Land and Good Health and Well-being.
Module content:
Introduction to general vertebrate diversity; African vertebrate diversity; vertebrate structure and function; vertebrate evolution; vertebrate relationships; aquatic vertebrates; terrestrial ectotherms; terrestrial endotherms; vertebrate characteristics; classification; structural adaptations; habits; habitats; conservation problems; impact of humans on other vertebrates. The module addresses the sustainable development goals of Life below Water and Life on Land.
Minimum credits: 144
Core = 72
Elective = 72
Additional information:
Single major track:
Dual major track:
Module content:
Overview of higher cognitive functions and the relations between psyche, brain and the immune system. Practical work: Applied practical work with specific examples drawn from South African case studies taught within the framework of the UN Sustainable Development Goal 3 (Good Health and Well-being).
Module content:
During this module the biology of cellular processes such as the cell cycle, cell death, migration and their related cellular signalling pathways will be discussed as well as their role in early stage embryology and age-related pathologies. Practical work: Exposure to applied molecular biology techniques with specific examples drawn from South African case studies taught within the framework of the UN Sustainable Development Goal of Good Health and Well-being (Sustainable Development Goal 3).
Module content:
Mechanisms of muscle contraction and energy sources. Cardio-respiratory changes, thermo-regulation and other adjustments during exercise. Use and misuse of substances to improve performance. Practical work: Applied practical work with exercise descriptions for the South African context taught within the framework of the UN Sustainable Development Goal 3 (Good Health and Well-being).
Module content:
Integration of all the human physiological systems. Practical work: Applied practical work.
Module content:
Structure, function, bioinformatics and biochemical analysis of (oligo)nucleotides, amino acids, proteins and ligands – and their organisation into hierarchical, higher order, interdependent structures. Principles of structure-function relationships, protein folding, sequence motifs and domains, higher order and supramolecular structure, self-assembly, conjugated proteins, post-translational modifications. Molecular recognition between proteins, ligands, DNA and RNA or any combinations. The RNA structural world, RNAi, miRNA and ribosomes. Cellular functions of coding and non-coding nucleic acids. Basic principles of mass spectrometry, nuclear magnetic resonance spectroscopy, X-ray crystallography and proteomics. Protein purification and characterisation including, pI, molecular mass, amino acid composition and sequence. Mechanistic aspects and regulation of information flow from DNA via RNA to proteins and back. Practical training includes hands-on nucleic acid purification and sequencing, protein production and purification, analysis by SDS-PAGE or mass spectrometry, protein structure analysis and 3D protein modelling.
Module content:
Regulation of metabolic pathways. Analysis of metabolic control. Elucidation of metabolic pathways with isotopes. Metabolomics. Coordinated regulation of glycolysis/gluconeogenesis and glycogen breakdown/synthesis. Overview of homone action. Metabolism of xenobiotics. Hormonal regulation of feul metabolism. Metabolic adaptions during diabetes. Obesity and the regulation of body mass. Obesity, metabolic syndrome and Type 2 diabetes (T2D). Management of T2D with diet, exercise and medication. Practical sessions cover tutorials on case studies and biochemical calculations, and hands-on isolation of an enzyme, determination of pH and temperature optima, determination of Km and Vmax, enzyme activation and enzyme inhibition.
Module content:
Visualising cell structure and localisation of proteins within cells. Cell ultrastructure. Purification of subcellular organelles. Culturing of cells. Biomembrane structure. Transmembrane transport of ions and small molecules and the role of these processes in disease. Moving proteins into membranes and organelles. Vesicular traffic, secretion, exocytosis and endocytosis. Cell organisation and movement motility based on the three types of cytoskeletal structures including microfilaments, microtubules and intermediate filaments as well as their associated motor proteins. Cell-cell and cell-matrix adhesion through corresponding proteins and morphological structures. Practical training includes tutorials on cytometry and microscopy, mini-research projects where students are introduced and guided through aspects of research methodology, experimental planning techniques associated with cellular assays, buffer preparation, active transport studies in yeast cells, structure-function analyses of actin and binding partners.
Module content:
Molecular mechanisms behind exogenous and endogenous diseases. Foundational knowledge of the immune system, with innate-, adaptive- and auto-immunity (molecular mechanisms of the maintenance and failure of the recognition of foreign in the context of self in the mammalian body) being some of the key concepts. Molecular pathology and immunobiochemistry of exogenous diseases against viral, bacterial and parasitic pathogens with a focus on the human immunodeficiency virus (HIV), tuberculosis (TB) and malaria. Endogenous disease will describe the biochemistry of normal cell cycle proliferation, quiescence, senescence, differentiation and apoptosis, and abnormal events as illustrated by cancer. Tutorials will focus on immunoassays, vaccines, diagnostic tests for diseases and drug discovery towards therapeuticals.
Module content:
Introduction to plant ecophysiology and plants response to environmental stress. Understanding how various biotic and abiotic factors affect plant metabolic processes, including photosynthesis and respiration. Emphasis is placed on the efficiency of the mechanisms whereby C3-, C4 and CAM-plants bind CO2 and how they are impacted by the environment. To understand the functioning of plants in diverse environments, the relevant structural properties of plants, the impact of soil composition, water flow in the soil-plant air continuum and long distance transport of assimilates will be discussed. Students will research a topic relevant to plant ecophysiology and present this in the form of an oral presentation. Students will conduct a practical project to study the effects of environmental factors on C3 and C4 plant growth and physiology. Students will present the report in a written format according to the guidelines of a relevant scientific journal. Relevant readings will be used to highlight the alignment of the module with the Sustainable Development Goals, with emphasis placed on climate action.
Module content:
The module will include a review on the discovery and use of plant medicines and phyto-therapeutically important molecules obtained from plants. Certain aspects of natural product chemistry i.e. the biosynthesis, ecological role and toxicity of the three main classes of secondary compounds; terpenoids, phenolics, and alkaloids are discussed. An introduction to the principles and applications of metabolomics is presented. The role of these natural products in defense against microorganisms and herbivores is reviewed during the module. The importance of ethnobotany and phylogenetics in modern drug discovery from biodiversity will presented along with legal and ethical considerations surrounding bioprospecting. This will follow on with modern theories and practices regarding sustainable utilisation and conservation of medicinal plants. The basics of alternative medicines, with an emphasis on traditional African and Chinese medicines, are also discussed as well as current evidence-based research and product development derived from these. Biotechnological approaches to medicinal natural product production, ‘farmer to pharma’, will be covered, including plant cell culture and bioreactors. Practical sessions on drug discovery approaches using chromatographic techniques for phytochemical analysis of secondary metabolites such as tannins, alkaloids, and saponins are conducted. Bioassays on micro-organisms are also done during the practical sessions in order to develop the skills for the potential discovery of new antibiotics.
Module content:
Theory: Molecular quantum mechanics. Introduction: Shortcomings of classical physics, dynamics of microscopic systems, quantum mechanical principles, translational, vibrational and rotational movement. Atomic structure and spectra: Atomic hydrogen, multiple electron systems, spectra of complex atoms, molecular structure, the hydrogen molecule ion, diatomic and polyatomic molecules, structure and properties of molecules. Molecules in motion: Viscosity, diffusion, mobility. Surface chemistry: Physisorption and chemisorption, adsorption isotherms, surface tension, heterogeneous catalytic rate reactions, capillarity.
Module content:
Separation methods: Extraction, multiple extraction, chromatographic systems. Spectroscopy: Construction of instruments, atomic absorption and atomic emission spectrometry, surface analysis techniques. Mass spectrometry. These techniques are discussed in terms of their use in environmental analysis and the value they contribute to meeting the UN sustainable development goals (#3,6 & 11). Instrumental electrochemistry. The relevance of electrochemistry to providing affordable and clean energy (UN SDG#7) is addressed.
Module content:
Theory: NMR spectroscopy: applications. Aromatic chemistry, Synthetic methodology in organic chemistry. Carbon-carbon bond formation: alkylation at nucleophilic carbon sites, aldol and related condensations, Wittig and related reactions, acylation of carbanions (Claisen condensation). Practical: Laboratory sessions are designed to develop the rational thinking behind the design of organic chemistry experiments. An industrial project specifically prepares students for work in SA industry context and honours projects. As part of this practical programme the UN sustainable development goals must be considered in evaluating the best industrial process.
Module content:
Theory: Structure and bonding in inorganic chemistry. Molecular orbital approach, diatomic and polyatomic molecules, three-centre bonds, metal-metal bonds, transition metal complexes, magnetic properties, electronic spectra, acid-base concepts, non-aqueous solvents, special topics.
Module content:
The undergraduate pharmacology module introduces students to general pharmacological principles, routes of administration, pharmacokinetics and pharmacodynamics. Furthermore, disease treatment with relation to disorders of the cardiovascular, inflammatory and autonomic nervous system is discussed, as well as anaesthesia, asthma, diabetes, diuresis, obesity and pain.
Module content:
Hormones, drugs that act on the histaminergic, serotonergic, and dopaminergic receptors. Pharmacotherapy of diabetes mellitus, schizophrenia, depression, obesity, anxiety, insomnia, gastro-intestinal diseases. Anticoagulants, antimicrobial drugs.
Module content:
Problem-orientated module, with the emphasis on occupational health and safety in the industrial environment. Integration of different physiological systems is required. Practical work: Exposure to occupational hygiene measurement techniques. *Students interested in pursuing postgraduate studies in OHS must take FLG 322.
Module content:
Regulation of gene expression in eukaryotes: regulation at the genome, transcription, RNA processing and translation levels. DNA elements and protein factors involved in gene control. The role of chromatin structure and epigenetic changes. Technology and experimental approaches used in studying eukaryotic gene control. Applications of the principles of gene control in eg cell signaling pathways, development cancer and other diseases in humans.
Module content:
A unifying framework for biology. Mechanisms involved in the evolution of genes, genomes and species. Comparative genomics across the kingdoms of life. Phylogenetic inference. Applications of phylogenetics and evolutionary genomics research, including relevance to sustainable development goals for food security, good health and the biosphere.
Module content:
Processes that affect genetic evolution: mutation, drift, natural selection and recombination. Fisher-Wright and coalescence models. Groupings of genes: linkage, inbreeding, population structure and gene flow. Neutral and nearly neutral theory. Quantitative genetics and the phenotype. Optimality. Adaptation. Levels of selection in sex ratios and conflict. Reproductive value and life history. Relatedness and kin selection. Sexual reproduction and selection. Genomic complexity and neutrality.
Module content:
Application of modern genetics to human variability, health and disease. Molecular origin of Mendelian and multifactorial diseases. The use of polymorphisms, gene mapping, linkage and association studies in medical genetics. Genetic diagnosis: application of cytogenetic, molecular and genomic techniques. Congenital abnormalities, risk assessment and genetic consultation. Prenatal testing, population screening, treatment of genetic diseases and gene-based therapy. Pharmacogenetics and cancer genetics. Ethical aspects in medical genetics.
Module content:
Introduction to the viruses as a unique kingdom inclusive of their different hosts, especially bacteria, animals and plants; RNA and DNA viruses; viroids, tumour viruses and oncogenes, mechanisms of replication, transcription and protein synthesis; effect on hosts; viral immunology; evolution of viruses.
Module content:
DNA replication and replication control. DNA recombination. DNA damage and repair. Genetics of bacteriophages, plasmids and transposons. Bacterial gene expression control at the transcriptional, translational and post-translational levels. Global regulation and compartmentalisation.
Module content:
Isolation of clonable DNA (genomic libraries, cDNA synthesis) cloning vectors (plasmids, bacteriophages, cosmids) plasmid incompatibility and control of copy number. Ligation of DNA fragments, modification of DNA end and different ligation strategies. Direct and indirect methods for the identification of recombinant organisms. Characterization (polymerase chain reaction, nucleic acid sequencing) and mutagenisis of cloned DNA fragments. Gene expression in Gram negative (E.coli) Gram positive (B.subtilis) and yeast cells (S.cerevisea). Use of Agrobacterium and baculoviruses for gene expression in plant and insect cells respectively. Applications in protein engineering, diagnostics and synthesis of useful products.
Module content:
Interactions between microbes and their abiotic environment; microbial interaction with other strains of the same and other species; microbial interactions across kingdoms; pathogenic interactions between microbes and plant or animal hosts; mutualistic interactions between microbes and their hosts; introduction to systems biology.
Module content:
Scientific approach to ecology; evolution and ecology; the individual and its environment; population characteristics and demography; competition; predation; plant-herbivore interactions; regulation of populations; population manipulation, human population. Examples throughout the module are relevant to the sustainable development goals of Life on Land and Good Health and Well-being.
Module content:
Mammalian origins and their characteristics: evolution of African mammals; structure and function: integument, support and movement; foods and feeding; environmental adaptations; reproduction; behaviour; ecology and biogeography; social behaviour; sexual selection; parental care and mating systems; community ecology; zoogeography. Special topics: parasites and diseases; domestication and domesticated mammals; conservation. The module addresses the sustainable development goals of Life on Land and Good Health and Well-being.
Module content:
This module focuses on the integration of physiological systems in the context of animal form and function, and the ways in which evolution shapes the physiological processes that determine the energy, water and nutrient fluxes between animals and their environments. Topics covered include: (i) circulation, gas exchange and excretion; (ii) nutritional ecology; (iii) osmoregulation and thermoregulation; and (iv) reproductive physiology. The major focus of this module is to understand the major sources of physiological diversity, namely scaling, phylogenetic inertia, adaptation and phenotypic plasticity, and applying this knowledge to conceptually link physiological processes at the cellular level to macrophysiological patterns at a global scale. Many examples used in this module are directly relevant to the sustainable development goals of Good Health and Well-being, Sustainable Cities and Communities, Climate Action and Life on Land.
Module content:
The history of behavioural ecology. A causal, developmental, evolutionary and adaptive approach. Sensory systems and communication. Sexual selection, mate choice and sperm competition. Kin selection and group living. Special reference to social insects. The behavioural ecology of humans. Phylogenetic basis of behavioural analysis. The role of behavioural ecology in conservation planning. The module covers sustainable development goals 1-10 and 12-15.
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